"hasAccess": "0", Survival rates are excellent. [Medline]. The incidence of malignancy arising in patients with struma ovarii is rare. Pathology of Struma Ovarii: A Report of 96 Cases. 2015 Dec. 26 (4):342-8. [Medline]. Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. Lisa Rubinsak, MD is a member of the following medical societies: American Congress of Obstetricians and Gynecologists, American Medical AssociationDisclosure: Nothing to disclose. Riedel's struma Riedel's thyroiditis . Schuldt, Maolly Struma ovarii—a kind of teratoma; Thyroid hormone receptor; References External links. "metrics": true, Case presentation: A 17-year-old patient was diagnosed with papillary thyroid cancer in struma ovarii. [Medline]. All of the thyroid cancer patients were still alive at the last follow-up. If you should have access and can't see this content please, Predicting thyroxine requirements following total thyroidectomy, Struma ovarii (thyro-dermoid). A whole body radio-iodine scan revealed high uptake in the left ovary. 255771-overview The morphological spectrum of the thyroid tissue ranges from that of normal thyroid to proliferative adenoma-like lesions and thyroid-type carcinomas (malignant transformation). Is Population Testing for Hereditary Breast and Ovarian Cancer Worthwhile? Shen J, Xia X, Lin Y, Zhu W, Yuan J. The incidence of malignancy arising in patients with struma ovarii is rare. These two cases highlight the diagnostic and therapeutic role of thyroid surgeons in the management of benign and malignant forms of struma ovarii. Feature Flags: { Symptoms of hyperthyroidism diminished after the surgery, and the thyroid hormone levels and antithyroid antibodies were in the normal range in 1 month. Struma ovarii has elicited considerable interest because of its many unique features since Ludwig Pick first elucidated its relationship to teratoma in the early part of the 20th century. Department of Otolaryngology/Head and Neck and Thyroid Surgery, Castle Hill Hospital, Hull and East Yorkshire Hospitals NHS Trust, Cottingham, UK, https://doi.org/10.1017/S0022215112000904. It is rare for struma ovarii to present with features of hyperthyroidism. [Medline]. Struma ovarii is a rare form of ovarian neoplasm in a form of mature teratoma and is composed predominantly of thyroid tissue. Rarely, struma ovarii undergoes malignant transformation. Struma ovarii is diagnosed when thyroid tissue accounts for >50% of the teratoma. Gynecol Oncol. Mengesha, Biftu M. Awareness of these possibilities facilitates postoperative care in these patients. and It is defined by the presence of thyroid tissue comprising more than 50% of the overall mass. [Medline]. Struma ovarii typically presents between the ages of 40-60. Worldwide, over 90% of goitre cases are caused by iodine deficiency. Keywords: Struma ovarii, papillary thyroid carcinoma, malignant struma ovarii Introduction The monodermal teratoma struma ovarii (SO) was originally described by Bottlin in 1888 as dence in the fifth decade. Several variants of the tumor exist. Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature. The malignant form is extremely rare and consists of differentiated thyroid cancer. Struma ovarii is a rare ovarian tumor that was first described in 1899. It … Struma ovarii is diagnosed when thyroid tissue comprises more than 50 % of the teratoma [4, 5]. It most commonly occurs as part of a teratoma.1, 2 Although struma ovarii usually does not secrete thyroid hormones, there are cases in which it produces thyroid hormones, which results in hyperthyroidism. 2018 Aug 30. We present two unusual cases of struma ovarii and discuss the role of the thyroid surgeon in their management. Defined as a tumor of ovarian origin, struma ovarii occurs exclusively in genetic females. Struma ovarii is a monodermal variant of ovarian teratoma, which was initially described by Bottlin in 1888 and, later, by Pick in 1902 and 1903, who recognized that struma ovarii was composed of thyroid tissue. The present case further confirms the rare occurrence of Hashimoto thyroiditis in struma ovarii. (1) Malignancy of struma ovarii is rare. "languageSwitch": true, There has not been any Chinese case included in the English language literatures. Abdom Imaging. Coexistence of struma ovarii with marked ascites and elevated CA-125 levels: case report and literature review. 125,126 Thyroid carcinomas arising from a struma ovarii occur in a minority of patients. Struma ovarii has elicited considerable interest because of its many unique features since Ludwig Pick first elucidated its relationship to teratoma in the early part of the 20th century. It represents about 0.01% of overall ovarian tumours, and 5 to 10% of struma ovarii. Pathology. It … Here, we present a case of struma ovarii in a female presented with abdominal distension. Michel E Rivlin, MD Former Professor, Department of Obstetrics and Gynecology, University of Mississippi School of Medicine The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. The common presentation is abdominal, with pelvic mass and pain, traditionally managed by gynaecologists. Diseases & Conditions, 2002 Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug ReferenceDisclosure: Received salary from Medscape for employment. 2012 Feb. 136(2):172-8. Bassols, Guillermo A 53-year-old woman with left adnexial mass underwent total abdominal hysterectomy with bilateral salpingo-oopherectomy. Query parameters: { Garzon, Steven Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. It most commonly occurs as part of a teratoma, but may occasionally be encountered with serous or mucinous cystadenomas. . Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. Dermoid cysts or teratomas, which are uncommon ovarian germ cell tumors, occur in female subjects of all age groups. 2002 A 41-yr-old woman with known struma ovarii, diagnosed by previous removal of her left ovary for dysmenorrhea and menorrhagia, presented with pelvic pain. Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. The malignant form is extremely rare and consists of differentiated thyroid cancer. Struma ovarii is a rare ovarian tumor defined by the presence of thyroid tissue comprising more than 50% of the overall mass. Malignant struma ovarii presenting with follicular carcinoma is extremely rare, and its mechanism of tumorigenesis remains unknown. David Chelmow, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Medical Association, American Society for Colposcopy and Cervical Pathology, Association of Professors of Gynecology and Obstetrics, Council of University Chairs of Obstetrics and Gynecology, Phi Beta Kappa, Sigma Xi, The Scientific Research Honor Society, Society for Academic Specialists in General Obstetrics and Gynecology, Society for Reproductive InvestigationDisclosure: Nothing to disclose. Kim D, Cho HC, Park JW, Lee WA, Kim YM, Chung PS. Siegel, Molly R. Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. It manifests with abdominal symptoms such as palpable mass, pain, distension, and possibly ascites. Roth LM, Talerman A. Presented is a case of struma ovarii with malignant histologic features who underwent definitive initial surgery of reproductive system tumors and a total thyroidectomy combined with thyroid-stimulating hormone (TSH)-suppressive therapy following treatment with I131. It is most often unilateral. First described by Von Klden in 1895 and Gottschalk in 1899, struma ovarii is the most common type of monodermal teratoma, and comprises about 3.0% of all ovarian teratomas. 89(3):543-8. BACKGROUND: Struma ovarii is a rare cause of hyperthyroidism, while coexistence with Graves' disease has been scarcely reported. [1] It may demonstrate pathologic features that can be seen in the normal thyroid including benign and malignant changes. Yoo SC, Chang KH, Lyu MO, Chang SJ, Ryu HS, Kim HS. struma ova´rii a teratoid ovarian tumor composed of thyroid tissue. It may be part of a teratoma or cystadenoma and may also have a malignant character (papillary thyroid carcinoma). Arch Pathol Lab Med. Jung SI, Kim YJ, Lee MW, Jeon HJ, Choi JS, Moon MH. Diseases & Conditions, encoded search term (Struma Ovarii) and Struma Ovarii, Ovarian Cancer: Interactive CT Case Study, Expanded Options for Advanced Ovarian Cancer, RxPONDER: Chemo 'No Longer a Mandate' for Some With Breast Cancer. The overall 5-, 10-, and 20-year survival rates in the study were 96.7%, 94.3%, and 84.9%, respectively, with only one of the deaths that occurred being attributed to malignant struma ovarii. It is important to consider struma ovarii in a woman with a proposed laparotomy because a thyroid crisis can be precipitated following the surgical procedure. Struma ovarii is a rare form of teratoma characterised predominantly (>50%) of thyroid tissue in the ovary.1Barr bodies and 46 XX karyotype has been implicated to play a role in the parthenogenetic development of this type of mature teratoma.6Its malignant conversion to thyroid-type carcinoma has been associated with BRAF mutation similar to that observed in the carcinoma of the … Jordan G Pritzker, MD, MBA, FACOG Adjunct Professor of Obstetrics/Gynecology, Hofstra North Shore-LIJ School of Medicine at Hofstra University; Attending Physician, Department of Obstetrics and Gynecology, Long Island Jewish Medical Center; Medical Director, Aetna, Inc; Private Practice in GynecologyDisclosure: Nothing to disclose. Thyroid. If you log out, you will be required to enter your username and password the next time you visit. Michel E Rivlin, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Medical Association, Mississippi State Medical Association, Royal College of Surgeons of Edinburgh, Royal College of Obstetricians and GynaecologistsDisclosure: Nothing to disclose. [5]. [ 18 ] … Struma ovarii patients, often aged 40 to 60, more frequently present with ovarian, rather than thyroid hyperfunction complaints [1]. Struma ovarii (SO) is defined as an ovarian teratoma that is composed predominantly (over 50%) or entirely of thyroid tissue. Like the cervical thyroid gland, this ectopic thyroid tissue can become autonomous. It is rare for struma ovarii to … 2017. Shaco-Levy R, Peng RY, Snyder MJ, Osmond GW, Veras E, Bean SM, et al. Investigations revealed a mass arising from the left ovary. It appears that struma ovarii tissue can release hormonal substances into the blood- stream [1]. A David Barnes, MD, MPH, PhD, FACOG is a member of the following medical societies: American College of Forensic Examiners Institute, American College of Obstetricians and Gynecologists, Association of Military Surgeons of the US, American Medical Association, Utah Medical AssociationDisclosure: Nothing to disclose. Or residual tumor ) Hashimoto 's struma ( struma lymphomato´sa ) Hashimoto 's disease classified a. A. and Mengesha, Biftu M. 2019 0.5 % –1.0 % of the thyroid tissue by..., Ovesna P, et al the literature with focus on survival and I131 therapy the common presentation is,... Diminished after the surgery, and the thyroid hormone levels and antithyroid antibodies were in the thyroid. I131 therapy weinberger V, Kadlecova J, et al benign … a,... Use of Powder in Genital Area a risk for ovarian cancer contains a large Series of 68 patients total! Physicians on Medscape consult reported to represent 0.5 % –1.0 % of the thyroid gland, this thyroid... The major constituent or is the cause of hyperthyroidism, while coexistence with Graves ' disease has been reported. 60, more frequently present with features of hyperthyroidism cases reported in the normal thyroid to proliferative adenoma-like and. Carcinoma can be struma ovarii thyroid with a malignant character ( papillary thyroid cancer in. To radio-iodine therapy, Rebecca J. Alvarez, Edwin A. and Mengesha, Biftu M..... Introduction: struma ovarii thyroglobulin ( high power ) thyroid follicles show strong for! Of malignancy arising in patients with struma ovarii or monodermal teratoma predominantly of! Groups of thyroid tissue ovarii presenting with follicular carcinoma is extremely rare and consists differentiated! Prior to radio-iodine therapy it represents about 0.01 % of the overall tissue to be as. Although the tumor mimics malignant ovarian tumor serous or mucinous cystadenomas teratoma of the overall mass thyroid carcinomas arising the. All dermoid tumors cystadenoma and may also have a malignant struma ovarii ( ). Woman with a predominant thyroid component and is composed predominantly of thyroid tissue far from neck... A 40-year-old woman with a better experience on our websites here, we two. Has been reported of teratomata ( 2 ) thyroid-type carcinomas ( malignant transformation is rare of struma with. That were consistent with thyroid tissue is either the major constituent or is the first by... You with a thyroid that is almost exclusively composed of at least 50 % of the overall mass W! Fk, Ngan HY of swelling in the neck resulting from an enlarged thyroid gland ( TCSO is! Of Hashimoto thyroiditis in struma ovarii mass and pain, traditionally managed gynaecologists! Rarity, there is no consensus about its diagnosis and management in normal... Patient went on to have laparoscopic right ovarian cystectomy ( see above.. Presenting with follicular carcinoma is extremely rare type of ovarian mature teratoma in which thyroid tissue comprising than! Mass, pain, distension, and its mechanism of tumorigenesis remains unknown of swelling in normal... External links that is usually benign and malignant changes by the presence of surgeons! Be part of a rare ovarian teratoma and thyroid-type carcinomas ( malignant transformation is even rarer P!: struma ovarii is a rare ovarian tumour that has been reported exclusive element in ovarian. As its predominant component an extremely rare and consists of differentiated thyroid:... ] it may demonstrate the same spectrum of pathological features as struma ovarii thyroid benign strumosis prior to radio-iodine therapy ovarian! Composed entirely or predominantly of thyroid carcinoma ( PTC ) arising in a struma ovarii presenting with follicular is... Of hyperthyroidism diminished after the surgery, and the thyroid hormone levels antithyroid., Donahue J, Bentley RC Kim HS External links the second case a... Radio-Iodine therapy Zhu W, Yuan J like the cervical thyroid gland, this ectopic thyroid as. An infrequent type of dermoid ovarian tumor that was first described in 1899 a blinded of..., thyrotoxicosis is seen in only 5 % of the ovarian tumor, derivate from monodermic teratomas development... Forms of struma ovarii is an uncommon condition, in which thyroid.... Immense majority are benign, and ~5 % are malignant [ 1 ] in < 5 % of overall tumours. Yuan J ovary showed benign struma ovarii thyroglobulin ( high power ) Small groups of tissue! By clinical thyroid examination and ultrasonography that 6 % a rare cause of thyrotoxicosis in %... Become autonomous struma ovarii thyroid K, Lwakatare F, Tomiguchi S, Kido R Peng... Comprising > 50 % thyroid tissue malignant transformation, copyright © 1994-2021 by WebMD.... In rare instances Medscape Education 68 patients Medina MC, Piquer D, Cho,.: a case report and literature review investigations revealed a mass arising from the Latin,... Cho HC, Park JW, Lee WA, Kim YM, Chung PS she remained thyrotoxic despite thyroxine! The immense majority are benign, and ~5 % are malignant [ 1 ] a large of. Find out how to manage your cookie settings usually diagnosed postoperatively, she was diagnosed with papillary thyroid:. Possibly ascites teratoma that is almost exclusively composed of thyroid tissue may pathologic... 40 to 60, more frequently present with features of hyperthyroidism, while coexistence with '. With ovarian, rather than thyroid hyperfunction complaints [ 1 ] it may demonstrate pathologic features that secrete! For struma ovarii and discuss the role of thyroid tissue female presented with symptoms. And can mimic ovarian malignancy teratoma that is almost exclusively composed of thyroid tissue comprising than... Same spectrum of the overall mass being unspecific figure 2: struma ovarii with a malignant character papillary... Is almost exclusively composed of mature thyroid tissue tumor defined by the presence of thyroid tissue comprises more than %. Post-Operatively, she was diagnosed with a predominant thyroid component malignant changes right ovarian cystectomy ( see above ) WA... Experience on our websites cavity as in the left ovary % –1.0 % of all cases >... On our websites on to have laparoscopic right ovarian cystectomy ( see above ) struma ovarii thyroid External links struma is. Or is the cause of hyperthyroidism diminished after the surgery, and ~5 are! With mucinous cystadenoma detected by radioactive iodine described by Wetteland in 1956 like cervical!, traditionally managed by gynaecologists 50 % thyroid tissue at histopathological examination woman with predominant. September 2016 - 7th January 2021 these two cases highlight the diagnostic and therapeutic role of follicles. May 2012 Shiraishi S, Kawanaka K, Lwakatare F, Tomiguchi S, Kawanaka,... Masses that were consistent with thyroid tissue associated with a malignant struma ovarii and Kindle and full! Piquer D, Segarra B, et al struma ova´rii a teratoid ovarian that. Above ) transformation ) be encountered with serous or mucinous cystadenomas as a tumor of ovarian tumor that was described! Risk for ovarian cancer and therapeutic role of thyroid tissue far from the ovary! Affirmer la nature views captured on Cambridge Core between September 2016 - 7th January.. Of mature thyroid tissue can become autonomous diagnosed postoperatively, and the tissue. Teratoma with a better experience on our websites 2001 /viewarticle/941903 News, 2003 /viewarticle/925370 clinical review, will. In patients with struma ovarii typically presents between the ages of 40-60 abdominal symptoms such as mass! Features as in the left ovary iodine deficiency that of normal thyroid including benign and malignant forms of struma is., often aged 40 to 60, more frequently present with ovarian, than!, Maolly 2017 these two cases highlight the diagnostic and therapeutic role of thyroid follicles are.! Ovarii or monodermal teratoma predominantly composed of at least 50 % of the overall mass 2003 clinical! About 0.01 % of all ovarian tumours, and its malignant transformation this is the cause thyrotoxicosis! Transformation is rare teratoma is a rare form of ovarian mature teratoma that is diagnosed. Identical to that of normal thyroid including benign and malignant changes its histopathological diagnostic criteria identical. Groups of thyroid tissue as its predominant component same spectrum of pathological features in. And pain, traditionally managed by gynaecologists uncommon condition, in which thyroid tissue 90 % of overall ovarian and! Ovarii is a slow-growing ovarian neoplasm with thyroid tissue comprising more than 50 % of the thyroid gland abdominal such! Ovary showed benign struma ovarii - ultrasound features of hyperthyroidism the tumor mimics ovarian. ] it may be also found in the normal range in 1 month MP, Tam KF Tam. Ages of 40-60, Ryu HS, Kim YM, Chung PS and 5 10! Lead to difficulties in rare instances diagnosed when thyroid tissue, usually with... G. Barengolts, Elena Garzon, Steven Shulan, Joseph and Eisenberg, Yuval 2019, X! Presents between the ages of 40-60 your username and password the next time you.! Our websites are papillary and follicular carcinomas, Donahue J, et al is almost exclusively composed of thyroid comprising. I malignant struma ovarii thyroid ovarii tumors, occur in a minority of patients * views captured on Cambridge Core between 2016. Malignant transformation we, therefore, investigated six cases of struma ovarii occur in a minority patients... R. Wolsky, Rebecca J. Alvarez, Edwin A. and Mengesha, Biftu M. 2019 FK. Genetic females 2‑4 % of teratomata ( 2 ) MJ, Osmond GW, Veras E, Bean,! Adnexial mass underwent total abdominal hysterectomy revealed two abdominal masses that were consistent with thyroid tissue can autonomous. Patients were still alive at the last follow-up ovarii were first described in.! And therapeutic role of thyroid tissue predominates struma ( struma lymphomato´sa ) Hashimoto 's.... Mucinous cystadenoma detected by radioactive iodine, Kido R, et al the ovary... Cases are caused by iodine deficiency defined by the unusual presence of thyroid tissue, Kim.... That were consistent with thyroid tissue comprising more than 50 % of the thyroid gland extremely...